Unc13d ELISA Kit for Mouse(Mus musculus) | EIAab.comUnc13d ELISA Kit for Mouse(Mus musculus)

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Unc13d (Gene name),

Protein unc-13 homolog D (Protein name ), UN13D_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Unc13d;

Protein name:

Protein unc-13 homolog D;

Alternative:

Munc13-4;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with RAB27A and DOC2A. Both RAB27A and DOC2A can simultaneously bind UNC13D.

Function:

Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis (By similarity). Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.

Subcellular Location:

Cytoplasm Membrane Peripheral membrane protein Late endosome Recycling endosome Lysosome Colocalizes with cytotoxic granules at the plasma membrane (By similarity). Localizes to endosomal exocytic vesicles.

Protein Attributes:

Sequence length:

1085

Sequence:

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1050:

1085:

DPILRLLESR | KGDREAQAFV | KLRRQRAKQA | SQHAP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

B2RUP2

UniGene:

Mm.259460

SMR:

B2RUP2

KEGG:

mmu:70450

Pfam:

PF00168

Uniprot:

B2RUP2

FOR

ELISA Kit for Mouse Protein unc-13 homolog D

Cat.:

E4438r

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Manual:

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96T

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ELISA Kit for Mouse Protein unc-13 homolog D

Cat.:

E4438h

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MSDS:

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Packing:

96T

ELISA Kit for Mouse Protein unc-13 homolog D

Cat.:

E4438m

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96T

CLIA Kit for Mouse Protein unc-13 homolog D

Cat.:

U4438r

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Protein unc-13 homolog D

Cat.:

U4438h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Protein unc-13 homolog D

Cat.:

U4438m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Protein unc-13 homolog D

Cat.:

P4438Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Protein unc-13 homolog D

Cat.:

P4438Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Protein unc-13 homolog D

Cat.:

P4438Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Protein unc-13 homolog D

Protein for Mouse Protein unc-13 homolog D

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis."
Crozat K. , Hoebe K. , Ugolini S. , Hong N.A. , Janssen E. , Rutschmann S. , Mudd S. , Sovath S. , Vivier E. , Beutler B.
J. Exp. Med.204:853-863(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 792-814;DISRUPTION PHENOTYPE
strain: C57BL/6.
2.

Crozat K. , Hoebe K. , Ugolini S. , Hong N.A. , Janssen E. , Rutschmann S. , Mudd S. , Sovath S. , Vivier E. , Beutler B.
J. Exp. Med.205:737-737(2008)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
3.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Brain.
5.

"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N. , Kikuno R.F. , Ohara R. , Inamoto S. , Nagase T. , Ohara O. , Koga H.
Submitted (2005-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 193-1085 (ISOFORM 2)
tissue: Spleen.
6.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
7.

"Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells."
Higashio H. , Nishimura N. , Ishizaki H. , Miyoshi J. , Orita S. , Sakane A. , Sasaki T.
J. Immunol.180:4774-4784(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RAB27A AND DOC2A;SUBCELLULAR LOCATION;TISSUE SPECIFICITY

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